Expression of Caspase-9 in Early and Locally Advanced Stage Squamous Cell Lung Cancer

Autor:	Arzu Yaren, Ferda Bir, Serkan Değirmencioğlu, Ahmet Ergin, Canan Karan, Gamze Gököz Doğu, Burcu Yapar Taskoylu, Aydın Demiray, Atike Gökçen Demiray, Hakan Akca, Umut Çakiroğlu, Nail Özhan
Rok vydání:	2020
Předmět:	Caspase-9 Oncology biology business.industry Locally advanced Cancer research biology.protein Medicine Stage (cooking) business Squamous cell lung cancer
Zdroj:	Journal of Oncological Sciences. 6:147-152
ISSN:	2452-3364 2651-4532
Popis:	Objective:Apoptosis plays a critical role in carcinogenesis. Intracellular proteases known as caspase-9 directly or indirectly playroles inactivating apoptosis. In this study, we aimed to investigate the effect of caspase-9 level in lung skuamous cancer tumor tissues on lymphnode metastasis, clinicopathologic parameters and prognosis. Material and Methods: The study included 50 patients diagnosed with squamous cell lung cancer. The caspase-9 level in the tumor and metastatic lymph nodes was assessed using real time-polymerase chain reaction(RT-PCR) methods. Results: The median age of the patients was 61 years (range, 54-68 years). All patients were men and smokers. Theaverage duration of follow-up was 50.26±39.21 months, and progression-free survival was 26.34±19.50 months. Among 50 patients, 22 (44%)had lymph node metastasis. The caspase-9 level was studied in tumors with and without lymph node metastasis. Moreover, the caspase-9 levels in tumors with lymph node metastasis were statistically and significantly lower than tumors without lymph node metastasis (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc43198014e3be443199b57dce1e5c0 https://doi.org/10.37047/jos.2020-76948 Zobrazit plný text záznamu