Lessons from the Embryonic Neural Stem Cell Niche for Neural Lineage Differentiation of Pluripotent Stem Cells
| Autor: | Valeriya Solozobova, Jan Pruszak, Nicolas Wyvekens |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pluripotent Stem Cells
Embryonic stem cells Cancer Research Cellular differentiation Cell Communication Embryoid body Biology Article Animals Humans Surface molecules Induced pluripotent stem cell Cell potency Neural stem cells Extracellular Matrix Proteins Cell Polarity Membrane Proteins Cell Differentiation Stem cell niche Extracellular matrix Cell Biology Embryonic stem cell Neural stem cell Cell biology Neuroepithelial cell Induced pluripotent stem cells Differentiation Self-renewal Intercellular Signaling Peptides and Proteins Stem cell Growth factors Signal Transduction Developmental Biology |
| Zdroj: | Stem Cell Reviews |
| ISSN: | 1550-8943 |
| DOI: | 10.1007/s12015-012-9381-8 |
| Popis: | Pluripotent stem cells offer an abundant and malleable source for the generation of differentiated cells for transplantation as well as for in vitro screens. Patterning and differentiation protocols have been developed to generate neural progeny from human embryonic or induced pluripotent stem cells. However, continued refinement is required to enhance efficiency and to prevent the generation of unwanted cell types. We summarize and interpret insights gained from studies of embryonic neuroepithelium. A multitude of factors including soluble molecules, interactions with the extracellular matrix and neighboring cells cooperate to control neural stem cell self-renewal versus differentiation. Applying these findings and concepts to human stem cell systems in vitro may yield more appropriately patterned cell types for biomedical applications. |
| Databáze: | OpenAIRE |
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