Evaluation of the growth rates and related prognostic factors in radiation-induced meningiomas

Autor: Christian Joachim Entenmann, Adéla Bubeníková, Jana Blažková, Michal Zápotocký, Jarmila Kruseová, David Sumerauer, Kateřina Trková, Vladimíra Sochová, Miroslav Koblížek, Martin Kynčl, Běla Malinová, Ondřej Bradáč, Vladimír Beneš
Rok vydání: 2022
Předmět:
Zdroj: Journal of Neuro-Oncology. 161:155-163
ISSN: 1573-7373
0167-594X
DOI: 10.1007/s11060-022-04209-y
Popis: Literature dedicated to growth patterns and growth rate influencing factors of radiation-induced meningiomas (RIMs) is limited. To deliver new insights into the topic, a volumetric growth analysis of RIMs was performed.This single-center, retrospective cohort study included patients diagnosed with intracranial meningioma who received radiation treatment at least 5 years before the RIM diagnosis. Volumetric analysis of individual RIMs was performed using 3D volumetry at the time of RIM diagnosis and during follow-up. RIM growth was determined by calculating absolute (AGR), and relative (RGR) growth rates. Prognostic factors associated with RIM growth were evaluated.A total of 26 patients with 33 meningiomas were enrolled in the study and radiologically/clinically followed up during a median duration of 5.6 years (IQR 3.9-8.8 years). Median AGR was 0.19 cmTo diagnose RIM as early as possible comprehensive MRI surveillance is required. Younger patients with shorter latency periods may profit from shortened MRI intervals, with further management being dependent on the growth rate and eventual symptomatology.
Databáze: OpenAIRE
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