Mortality prediction by acute kidney injury biomarkers in comparison with serum creatinine
| Autor: | Kengo Mayumi, Naoki Yahagi, Kent Doi, Toshifumi Asada, Ryota Inokuchi, Takehiro Matsubara, Rei Isshiki, Maki Sumida, Masaomi Nangaku, Takahiro Hiruma, Takeshi Ishii, Miyuki Yamamoto, Eisei Noiri |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis Urinary system Clinical Biochemistry urologic and male genital diseases Biochemistry Gastroenterology Cohort Studies chemistry.chemical_compound Internal medicine medicine Humans Mortality prediction Intensive care medicine Aged Creatinine urogenital system business.industry Acute kidney injury Acute Kidney Injury Middle Aged medicine.disease female genital diseases and pregnancy complications Derivation cohort chemistry N acetyl β d glucosaminidase Female business Validation cohort Biomarkers |
| Zdroj: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 19(8) |
| ISSN: | 1366-5804 |
| Popis: | Objectives: To investigate the performance of acute kidney injury (AKI) biomarkers for mortality prediction.Materials and methods: Cutoff values of urinary L-type fatty acid-binding protein (L-FABP) and N-acetyl-β-d-glucosaminidase (NAG) for AKI diagnosis in ICU were determined in the derivation cohort. The performance of these AKI biomarkers for mortality prediction was evaluated in the validation cohort with stratification of serum-creatinine based AKI diagnosis.Results: Mortality in the AKI patients diagnosed by serum creatinine was increased remarkably when urinary L-FABP and NAG were positive.Conclusions: These AKI biomarkers can specifically detect high-risk patients among creatinine-base diagnosed AKI. |
| Databáze: | OpenAIRE |
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