Effects of Oral Hyaluronic Acid Administration in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury
| Autor: | J. I. Redondo, C. Soler, Juan José Ramos-Plá, Víctor Moratalla, Claudio Iván Serra Aguado, Sergi Segarra |
|---|---|
| Přispěvatelé: | Producción Científica UCH 2021, UCH. Departamento de Medicina y Cirugía Animal |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hyaluronic acid - Therapeutic use Osteoarthritis in dogs 040301 veterinary sciences Veterinary medicine canine Osteoarthritis Osteoartritis en los perros - Tratamiento Ácido hialurónico - Uso terapéutico Placebo Article cranial cruciate ligament 0403 veterinary science Cruciate ligament Ligamentos - Cirugía 03 medical and health sciences chemistry.chemical_compound Tibial tuberosity advancement synovial fluid Oral administration Hyaluronic acid hyaluronic acid SF600-1100 medicine Synovial fluid paraoxonase-1 Ligaments - Surgery 030304 developmental biology Dogs - Surgery 0303 health sciences General Veterinary biology business.industry Haptoglobin 04 agricultural and veterinary sciences medicine.disease Surgery Perros - Cirugía osteoarthritis medicine.anatomical_structure chemistry QL1-991 biology.protein Animal Science and Zoology business Zoology |
| Zdroj: | Animals, Vol 11, Iss 1264, p 1264 (2021) Animals Volume 11 Issue 5 Animals : an Open Access Journal from MDPI CEU Repositorio Institucional Fundación Universitaria San Pablo CEU (FUSPCEU) |
| ISSN: | 2076-2615 |
| Popis: | Hyaluronic acid (HA) intraarticular injection is used in the management of osteoarthritis in veterinary medicine. However, HA oral administration is less common given the scarce currently available scientific evidence. This study was aimed at evaluating the effects of oral HA administration on synovial fluid concentrations of several selected biomarkers in dogs with cranial cruciate ligament (CCL) injury operated on using the tibial tuberosity advancement (TTA) technique. Fifty-five dogs were included in this prospective, randomized, double-blind, clinical study they were randomly assigned to receive either a placebo (group A n = 25) or HA (group B n = 30) orally for 10 weeks. Synovial fluid samples were obtained before surgery, and at 10 weeks postoperatively to measure concentrations of HA, haptoglobin, nitric oxide, and paraoxonase-1. After 10 weeks, group HA showed a significant increase in HA concentration (p = 0.0016) and a significant decrease in PON-1 concentration (p = 0.011) compared to baseline. In conclusion, post-op oral HA administration in canine patients with CCL injury leads to improvements in osteoarthritis biomarkers, namely higher synovial fluid HA concentrations and reduced synovial fluid paraoxonase-1 concentrations. These findings support the bioavailability of orally-administered HA and its usefulness in improving biomarkers of osteoarthritis. |
| Databáze: | OpenAIRE |
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