Unexpected histopathology results following routine examination of cholecystectomy specimens: How big and how significant?
| Autor: | Abdulkarim Hasan, Mohamad Baheeg, Amal Ismail, Adel A. Ibrahim, Khalid Nafie, Mohammed Yousef Aldossary, Reda Elhawary, Khaled Monazea, Kamal Rady |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Cholecystitis Histopathological examination medicine Carcinoma Cholecystectomy Phrygian cap Clinical significance business.industry Gallbladder General Medicine medicine.disease medicine.anatomical_structure Dysplasia 030220 oncology & carcinogenesis Cross-sectional Study 030211 gastroenterology & hepatology Surgery Histopathology Radiology Gallbladder carcinoma business |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| Popis: | Background Routine histopathological examination (RHPE) of all gallbladder specimens is required to detect the presence of gallbladder carcinoma (GBC) or any other pathology. The work aims to study the incidence and the clinical significance of detecting unusual gallbladder findings upon the RHPE of the referred cholecystectomy specimens to a histopathology laboratory section at a referral hospital in Saudi Arabia during one year period. Materials and methods From May 2019 to May 2020, all histopathology reports of 444 consecutive gallbladder specimens after elective and emergency cholecystectomies were retrospectively analyzed and divided into two groups; usual findings and unusual findings which were reviewed blindly by two other pathology consultants. Frequencies, descriptive statistics, normality test, and correlations were run. The Interrater reliability between clinical and histopathological diagnosis was assessed statistically by kappa test. Results The results of histopathological examination of these gallbladder specimens showed that chronic cholecystitis was found in 296 out of 444 total cases (66.7%), acute cholecystitis in 52 cases (11.7%), and other associated usual findings in 85 cases (19%). Three cases (0.7%) of incidental carcinomas and other three cases (0.7%) of dysplasia. Eosinophilic carcinomas were detected in two cases (0.45%), gallbladder complete septum was found in one case, and one case of Phrygian cap anomaly. All patients with gallbladder carcinoma were diagnosed incidentally during the histopathological examination. Conclusions RHPE of cholecystectomy materials are required to confirm the final diagnosis and document any other pathology. Failure to detect incidental occult carcinoma may be catastrophic, given the poor prognosis. Highlights • Unusual histopathology results were seen in 2.3% of the routinely examined cholecystitis cases. • Gallbladder carcinoma and also some rare lesions can be accidentally discovered during pathology examination. • Routine histopathological examination of cholecystectomies in our hospital during one year showed a significant clinical value. |
| Databáze: | OpenAIRE |
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