The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study
Autor: | Laura Bracco, Valentina Bessi, Sonia Padiglioni, Silvia Bagnoli, Sandro Sorbi, Salvatore Mazzeo, Benedetta Nacmias |
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Rok vydání: | 2019 |
Předmět: |
Male
Oncology Apolipoprotein E medicine.medical_specialty Neurology Apolipoprotein E4 National Adult Reading Test 03 medical and health sciences 0302 clinical medicine Cognitive Reserve Alzheimer Disease Internal medicine mental disorders medicine Humans Dementia Cognitive Dysfunction 030212 general & internal medicine Cognitive decline Risk factor Aged Cognitive reserve business.industry Neuropsychology Middle Aged medicine.disease Disease Progression Female Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies |
Zdroj: | Journal of Neurology. 266:487-497 |
ISSN: | 1432-1459 0340-5354 |
Popis: | The aim of this study was to evaluate the effect of cognitive reserve (CR), in progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). For this purpose, we followed up 263 patients (154 SCD; 109 MCI) for a mean time of 7 years. CR was assessed by the Test di Intelligenza Breve (TIB), functionally equivalent to the National Adult Reading Test. High CR resulted as a protective factor for progression from SCD to MCI. Age at conversion to MCI was delayed 9 years on average in SCD with high CR with respect to SCD with low CR. On the contrary, high CR resulted as a risk factor for progression from MCI to AD dementia only in APOE ε4 carriers. Conversion time from MCI to AD dementia was 3 years shorter in ε4 carriers with high CR than subjects with low CR and ε4 non-carriers with high CR. Consistent with the CR hypothesis, our results showed that higher levels of CR protect against the earliest clinical manifestations of AD. In line with the previous researches, we found an interaction between CR and APOE in progression from MCI to AD dementia. |
Databáze: | OpenAIRE |
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