Modeling the stem cell hypothesis: Investigating the effects of cancer stem cells and TGF-β on tumor growth
| Autor: | Emek Kose, Anna E Steinfeld, Elizabeth Zollinger, Allison L. Lewis, Samantha L. Elliott |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Antineoplastic Agents 02 engineering and technology Biology CD8-Positive T-Lymphocytes Models Biological Drug Administration Schedule Mice Immune system Cancer stem cell Transforming Growth Factor beta Neoplasms 0502 economics and business 0202 electrical engineering electronic engineering information engineering medicine Animals Humans Tumor growth Chemotherapy Treatment regimen Applied Mathematics 05 social sciences Cancer Reproducibility of Results General Medicine medicine.disease Gene Expression Regulation Neoplastic Computational Mathematics Treatment Outcome Modeling and Simulation Calibration Cancer research Neoplastic Stem Cells 020201 artificial intelligence & image processing Fluorouracil Stem cell Neoplasm Recurrence Local General Agricultural and Biological Sciences 050203 business & management Transforming growth factor |
| Zdroj: | Mathematical biosciences and engineering : MBE. 16(6) |
| ISSN: | 1551-0018 |
| Popis: | We propose a mathematical model to describe the interaction of cancer stem cells, tumor cells, and the immune system in order to better understand tumor growth in the presence of cancer stem cells. We consider the system in two scenarios: with no-treatment and with a chemotherapy treatment regimen. We develop a system of differential equations, fit the parameters to experimental data, and perform sensitivity and stability analysis. The model simulations show that the tumor cells grow as predicted with no-treatment and that with chemotherapy, which targets only the tumor cells, the cancer will eventually relapse. As chemotherapy does not target the cancer stem cells, we conclude that the tumor cells recover due to the presence of cancer stem cells. |
| Databáze: | OpenAIRE |
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