Evidence for a defective mitochondrial membrane in 1,2-dimethylhydrazine-induced colon adenocarcinoma in rat: Enhanced lipid peroxidation potential in vitro
| Autor: | R.H. Stevens, Larry W. Oberley, D.P. Loven, J.M. Graves, D.A. Cole, R.S. Rana, E.S. Meek |
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| Rok vydání: | 1980 |
| Předmět: |
Dimethylhydrazines
Male Lipid Peroxides Cancer Research Cell Membrane Adenocarcinoma Mitochondrion Biology medicine.disease_cause Malondialdehyde In vitro Mitochondria Rats Cell biology 1 2-Dimethylhydrazine Lipid peroxidation chemistry.chemical_compound Oncology chemistry Colonic Neoplasms Cancer cell medicine Animals Inner mitochondrial membrane Carcinogenesis |
| Zdroj: | Cancer Letters. 9:237-244 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(80)90093-2 |
| Popis: | Enhanced lipid peroxidation potential was measured in Holtzman rat colon tumors induced by chronic subcutaneous injection of 1,2-dimethyl-hydrazine as compared with normal colonic tissue. The peroxidation potentials were determined in the mitochondrial cellular components by measuring the ferrous-ascorbate induced formation of malondialdehyde. The tumor mitochondria were found to peroxidize at a rate 8-10-fold higher than the comparable normal tissue components. In addition, we found that the mitochondria from the cancer cells exhibited reduced NADH-cytochrome c reductase activity. These observations suggest an involvement of non-enzymatic free radical flux in DMH-induced carcinogenesis, which may be the result of structurally altered mitochondrial membranes. |
| Databáze: | OpenAIRE |
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