Novel recombinant congenic mouse strain developing arthritis with enthesopathy
| Autor: | Hiroaki Komori, Shiro Mori, Hisashi Oishi, Masato Nose, Naoko Tanda, Mitsuko R. Ito, Masao Ono, Mingcai Zhang, Masahiko Nishimura, Takahito Tsubaki |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Vasculitis Mice Inbred MRL lpr Pathology medicine.medical_specialty Knee Joint Ankylosis Congenic Immunoglobulins Arthritis urologic and male genital diseases Pathology and Forensic Medicine Arthritis Rheumatoid Mice Mice Congenic immune system diseases Synovitis Animals Medicine Rheumatoid factor Lymphocytes skin and connective tissue diseases Autoantibodies business.industry Enthesopathy Enthesitis Autoantibody General Medicine Flow Cytometry medicine.disease Disease Models Animal Rheumatoid arthritis Immunology Female medicine.symptom business Ankle Joint |
| Zdroj: | Pathology International. 58:407-414 |
| ISSN: | 1440-1827 1320-5463 |
| Popis: | Based on the hypothesis that the complex pathological and immunological manifestations of rheumatoid arthritis (RA) and the related diseases are under the control of multiple gene loci with allelic polymorphism, a recombinant congenic mouse strain was prepared between an MRL/Mp-lpr/lpr (MRL/lpr) strain, which develops arthritis resembling RA, and a non-arthritic strain C3H/HeJ-lpr/lpr (C3H/lpr). In MRL/lpr x (MRL/lpr x C3H/lpr) F1 mice, the mice developing severe arthritis were selected based on joint swelling to further continue intercrosses, and then an McH-lpr/lpr-RA1 (McH/lpr-RA1) strain was established and its histopathological phenotypes of joints and autoimmune traits were analyzed. Arthritis in McH/lpr-RA1 mice developed at a higher incidence by 20 weeks of age, compared with that in the MRL/lpr mice, who had severe synovitis (ankle, 60.3%; knee, 65.1%), and also fibrous and fibrocartilaginous lesions of articular ligamenta resembling enthesopathy (ankle, 79.4%; knee, 38.1%), resulting in ankylosis. The lymphoproliferative disorder was less, and serum levels of IgG and IgG autoantibodies including anti-dsDNA and rheumatoid factor were lower than those of both MRL/lpr and C3H/lpr strains. McH/lpr-RA1 mice may provide a new insight into the study of RA regarding the common genomic spectrum of seronegative RA and enthesopathy. |
| Databáze: | OpenAIRE |
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