Prognostic impact of stromal and intratumoral CD3, CD8 and FOXP3 in adjuvantly treated breast cancer: do they add information over stromal tumor-infiltrating lymphocyte density?
| Autor: | Flora Zagouri, Grigorios Xepapadakis, George Pentheroudakis, Maria Sotiropoulou, Alexandra Papoudou-Bai, Helen Gogas, Christos Christodoulou, Christos Markopoulos, Helen P. Kourea, George C. Zografos, Georgia-Angeliki Koliou, Kalliopi Petraki, Niki Arnogiannaki, Triantafyllia Koletsa, Vassiliki Kotoula, Ioannis Kostopoulos, Konstantine T. Kalogeras, Kyriaki Manousou, Angelos Koutras, V. Venizelos, Dimitrios Bafaloukos, Alexandros Iliadis, Elissavet Pazarli, George Fountzilas, Sofia Chrisafi, Kyriakos Chatzopoulos |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Cancer Research Stromal cell Anthracycline CD3 Complex Lymphocyte medicine.medical_treatment CD8 Antigens Immunology Breast Neoplasms Lower risk 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Lymphocytes Tumor-Infiltrating Biomarkers Tumor Immunology and Allergy Medicine Humans Stromal tumor Aged Chemotherapy business.industry Forkhead Transcription Factors Middle Aged medicine.disease Prognosis Lymphocyte Subsets medicine.anatomical_structure Oncology Chemotherapy Adjuvant Cancer research Immunohistochemistry Female Radiotherapy Adjuvant Stromal Cells business 030215 immunology Follow-Up Studies |
| Zdroj: | Cancer immunology, immunotherapy : CII. 69(8) |
| ISSN: | 1432-0851 |
| Popis: | Tumor-infiltrating lymphocytes (TILs) and their subsets contribute to breast cancer prognosis. We investigated the prognostic impact of CD3+, CD8+ and FOXP3+ TILs in patients with early intermediate/high-risk breast cancer treated with adjuvant anthracycline-based chemotherapy within two randomized trials conducted by our Group. We examined 1011 patients (median follow-up 130.9 months) and their tumors for total, stromal (s) and intratumoral (i) CD3, CD8 and FOXP3 lymphocyte density (counts/mm2) on tissue-microarray cores by immunohistochemistry. Morphological sTIL density on whole H&E-stained sections was also evaluated. The majority of TILs were CD3+. Total CD3 and CD8, sCD3 and sCD8, iCD3 and iCD8, sFOXP3 and iFOXP3 were strongly correlated (Spearman’s rho values > 0.6). High individual lymphocytic subsets and sTIL density were strongly associated with high tumor grade, higher proliferation and HER2-positive and triple-negative tumors (all p values |
| Databáze: | OpenAIRE |
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