RANKL-Expressing Ectopic Extramammary Paget’s Disease on the Lower Abdomen
| Autor: | Aya Kakizaki, Taku Fujimura, Akiko Hagiwara-Takita, Setsuya Aiba |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases Pathology medicine.medical_specialty MMP25 Single Case Dermatology Extramammary Paget's disease MMP7 CCL5 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine lcsh:Dermatology Tumor microenvironment biology business.industry RANKL lcsh:RL1-803 medicine.disease 030104 developmental biology medicine.anatomical_structure biology.protein Abdomen Extramammary Paget’s disease business |
| Zdroj: | Case Reports in Dermatology, Vol 8, Iss 2, Pp 130-135 (2016) Case Reports in Dermatology |
| ISSN: | 1662-6567 |
| Popis: | Ectopic extramammary Paget’s disease (EMPD) is a rare variant of EMPD that develops in nonapocrine regions. Since reports about ectopic EMPD are limited, little is known about the biological and immunological background of ectopic EMPD. In this report, we present a case of ectopic EMPD on the lower abdomen that expressed RANKL but lacked the expression of MMP7. As we previously reported, Paget’s cells express RANKL and MMP7, release soluble RANKL in the tumor microenvironment, and stimulate tumor-associated macrophages to produce tumor-loading factors in conventional EMPD. In our present case, both CCL5-expressing cells and MMP25-bearing cells were lacking, whereas substantial numbers of CCL5-expressing cells and MMP25-bearing cells were found in conventional EMPD. Our case suggested that the lack of MMP7 on Paget’s cells might be one of the possible explanations for the biology of ectopic EMPD. |
| Databáze: | OpenAIRE |
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