Serum estradiol level during withdrawal bleeding as a predictive factor for intermittent ovarian function in women with primary ovarian insufficiency
| Autor: | Hiroshi Uchida, Kaoru Miyazaki, Fumie Miki, Hirotaka Masuda, Tetsuo Maruyama, Sayaka Uchida |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Ovulation medicine.medical_specialty Metrorrhagia Pregnancy Rate Endocrinology Diabetes and Metabolism media_common.quotation_subject Physiology Ovary Primary Ovarian Insufficiency Biology Young Adult Follicle-stimulating hormone Oogenesis Endocrinology Japan Pregnancy medicine Humans Biotransformation Retrospective Studies media_common Gynecology Estradiol Female infertility Estrogens Fertility Agents Female medicine.disease Premature ovarian failure Pregnancy rate medicine.anatomical_structure ROC Curve Female medicine.symptom Infertility Female Follow-Up Studies |
| Zdroj: | Endocrine Journal. 62:93-99 |
| ISSN: | 1348-4540 0918-8959 2000-2009 |
| DOI: | 10.1507/endocrj.ej14-0189 |
| Popis: | The objective of this study was to assess the potential predictive factors for follicle growth, ovulation, and pregnancy rate in patients with primary ovarian insufficiency/premature ovarian failure (POI/POF). We enrolled 25 POI patients with desired fertility who were treated and monitored for a minimum of 7 months between the years of 2000-2009 into this retrospective study. The clinical, endocrinologic, chromosomal, and autoimmunologic parameters of these patients were collected. Furthermore, hormonal backgrounds on each of 620 treatment cycles were investigated. The main outcome measures were follicle growth, ovulation, and pregnancy rate. Four of 25 patients (16%) conceived while being monitored and undergoing treatment. Follicle growth, ovulation, and pregnancy rate were not significantly different as a function of parity, iatrogenic history (e.g., chemotherapy), age of disease onset, serum estradiol (E(2))/follicle stimulating hormone (FSH) level at the time of diagnosis, chromosomal abnormality, and positive autoantibody titer. The serum E2 levels on days 1-5 of withdrawal bleeding (Day 1-5 E(2)) were significantly higher in the cycles with successful follicle growth and ovulation than unsuccessful cycles (P |
| Databáze: | OpenAIRE |
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