Transplacental infection of Coxsackievirus B3 pathological findings in the fetus
| Autor: | Xenophon Kotsiakis, Hector Anninos, Nikolaos Spanakis, Anastasia E. Konstantinidou, Efstratios Patsouris, Garyfallia Syridou, Athanassios Tsakris |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Myocarditis Placenta Diseases Transplacental transmission Molecular Sequence Data Coxsackievirus Infections Cardiomegaly Coxsackievirus Ultrasonography Prenatal Fetus Pregnancy Virology medicine Humans Pregnancy Complications Infectious Fetal Movement Pneumonitis Arthrogryposis biology Base Sequence business.industry Histocytochemistry Transplacental Meningoencephalitis Calcinosis Abortion Induced medicine.disease biology.organism_classification Infectious Disease Transmission Vertical Enterovirus B Human Leukoencephalitis Acute Hemorrhagic Fetal Diseases Infectious Diseases Fetal movement Blood Vessels Female Chorionic Villi business Lung Diseases Interstitial Sequence Alignment |
| Zdroj: | Journal of medical virology. 79(6) |
| ISSN: | 0146-6615 |
| Popis: | Coxsackievirus intrauterine infection has been documented mostly on the basis of indirect evidence of transplacental transmission, with neonatal manifestations ranging from asymptomatic infection to meningoencephalitis, myocarditis, and generalized sepsis. This is the first report of prenatal findings and fetoplacental pathology in a third trimester fetus with coxsackie B3 transplacental infection confirmed by molecular techniques. Prenatal ultrasound detected severe reduction of fetal movements at the 27th week. Late onset fetal akinesia deformation sequence with mild arthrogryposis, necrotic meningoencephalitis with vascular calcifications, interstitial pneumonitis, mild myocardial hypertrophy, and chronic monocytic placental villitis were the cardinal findings at fetal autopsy following interruption of the pregnancy. |
| Databáze: | OpenAIRE |
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