Zinc deprivation and zinc repletion: effect on the response of rats to infection with Strongyloides ratti
| Autor: | P J Aggett, D Wakelin, D C Macdonald, P K Fenwick, C Huber |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Medicine (miscellaneous)
chemistry.chemical_element Zinc Biology Body weight Feces Animal science Immunity parasitic diseases Strongyloides medicine Helminths Animals Intestinal Diseases Parasitic Immunity Cellular Nutrition and Dietetics Body Weight Rats Inbred Strains medicine.disease Gained weight Diet Rats Intestines Strongyloidiasis chemistry Immunology Zinc deficiency Female Strongyloides ratti |
| Zdroj: | The American journal of clinical nutrition. 52(1) |
| ISSN: | 0002-9165 |
| Popis: | The course ofa subcutaneous weight-related infection with Strongyloides ratti was followed in rats fed diets containing either 3 mg Zn/kg diet (zinc deficient (Zn-)) or 40 mg Zn/kg diet (zinc adequate (Zn+)). At 19 d postinfection (dpi) the proportions of larvae persisting in the intestines as adult worms were 52 ± 2% (1± SEM) for Zn-, 39.5 ± 2.5% for pair-fed Zn- (Zn-PF), and 31.6 ± 3.2% for Zn+ (p < 0.001, analysis of variance); some Zn- rats were then transferred to the zinc-adequate diet (This was the zinc-repleted group (ZnR).) Both groups retained a group ofpair-fed controls (Zn- -PF and ZnRPF). Between 19 and 28 dpi ZnR animals gained weight faster than did Zn- animals and had heavier thymuses relative to body weight. Zinc deficiency enhances the establish- ment ofS ratti larvae in the intestine ofrats and alters the char- acteristics of intestinal expulsion of the nematodes; however, spontaneous cure was achieved by 38 dpi in both Zn- and con- trolgroups. AmJClinNutr 1990;52:173-7. |
| Databáze: | OpenAIRE |
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