Increased macrophage colony-stimulating factor levels in immune thrombocytopenic purpura

Autor:	Z R, Zeigler, C S, Rosenfeld, J J, Nemunaitis, E C, Besa, R K, Shadduck
Rok vydání:	1993
Předmět:	Adult Blood Platelets Male Purpura Thrombocytopenic Idiopathic Adolescent Platelet Count Macrophage Colony-Stimulating Factor Immunology Cell Biology Hematology Middle Aged Biochemistry Adrenal Cortex Hormones Immunoglobulin G hemic and lymphatic diseases Splenectomy Humans Female
Zdroj:	Blood. 81:1251-1254
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v81.5.1251.bloodjournal8151251
Popis:	Thrombocytopenia is a dose-limiting toxicity of macrophage colony- stimulating factor (M-CSF) in preclinical and initial phase I trials. Modulation of macrophage-mediated platelet destruction in immune thrombocytopenic purpura (ITP) may be affected by M-CSF activity. In this study, plasma levels of M-CSF were determined by a sensitive radioimmunoassay in 23 patients with ITP. These were compared with control levels measured in 24 healthy subjects. M-CSF levels were significantly higher in the ITP patients than in the control subjects (218 v 179, P < .02); however, there was a great deal of overlap. The highest M-CSF levels (median = 299 U/mL) were observed in three patients with Evan's syndrome. Patients with severe ITP (platelets < 25,000/microL) had intermediate M-CSF levels (median = 231 U/mL) and those with mild thrombocytopenia (> 25,000/microL) had normal levels (median = 173 U/mL). Sixteen patients were treated with corticosteroids: 10 responded and 6 did not. Median M-CSF levels were higher in those who failed to respond compared with responders (272 v 202, P < .05). These findings suggest M-CSF may influence macrophage- mediated platelet destruction in ITP.
Databáze:	OpenAIRE
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