Dietary N-carbamylglutamate and rumen-protected L-arginine supplementation during intrauterine growth restriction in undernourished ewes improve fetal thymus development and immune function
| Autor: | Fangfang Zhao, Juan J. Loor, Hao Zhang, Haitao Nie, Feng Wang, Tiewei Ma, Ziyu Wang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Intrauterine growth restriction Reproductive technology Thymus Gland Biology Arginine Umbilical cord Fetal Development 03 medical and health sciences Endocrinology Immune system Glutamates Pregnancy Internal medicine Genetics medicine Animals Molecular Biology Fetus Fetal Growth Retardation Sheep 0402 animal and dairy science Interleukin 04 agricultural and veterinary sciences Maternal Nutritional Physiological Phenomena medicine.disease 040201 dairy & animal science Diet 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Immune System Dietary Supplements Gestation Animal Science and Zoology Animal Nutritional Physiological Phenomena Female Developmental Biology Biotechnology |
| Zdroj: | Reproduction, fertility, and development. 30(11) |
| ISSN: | 1031-3613 |
| Popis: | The aims of the present study were to determine whether dietary supplementation with N-carbamylglutamate (NCG) and rumen-protected l-arginine (RP-Arg) to underfed Hu sheep would improve fetal thymus development and immune function. From Day 35 to Day 110 of gestation, 32 Hu ewes carrying twin fetuses were randomly allocated to one of four groups (n = 8 per group): 100% National Research Council (NRC)-recommended nutrient requirements (CON), 50% NRC recommendations (RES), 50% NRC recommendations supplemented with 20 g day−1 RP-Arg (RES+ARG), and 50% NRC recommendations supplemented with 5 g day−1 NCG (RES+NCG). Medullary thickness was increased (P 0.05). Concentrations of IgA, interleukin (IL)-1β and IL-10 in fetal umbilical cord blood were reduced (P 0.05) in both RES+ARG and RES+NCG ewes. These results indicate that dietary supplementation with NCG and RP-Arg could help alleviate the negative effects of intrauterine growth restriction on fetal thymus development and immune function. |
| Databáze: | OpenAIRE |
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