Early-Stage Loeffler's Endocarditis with Isolated Right Ventricular Involvement: Management, Long-Term Follow-Up, and Review of Literature
| Autor: | Kalgi Modi, Jagan Beedupalli |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Pathology Ventricular Dysfunction Right Hypereosinophilia 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine White blood cell Hypereosinophilic Syndrome medicine Endocarditis Eosinophilia Humans Radiology Nuclear Medicine and imaging Longitudinal Studies Chronic eosinophilic leukemia Hematology Evidence-Based Medicine business.industry Hypereosinophilic syndrome Eosinophil Middle Aged medicine.disease medicine.anatomical_structure Treatment Outcome Echocardiography 030220 oncology & carcinogenesis Steroids medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Echocardiography (Mount Kisco, N.Y.). 33(9) |
| ISSN: | 1540-8175 |
| Popis: | Loeffler's endocarditis is a clinical condition characterized by combination of three key findings: unexplained prolonged and marked eosinophilia (>1500 eosinophils/mm(3) ), absence of a primary cause of hypereosinophilia, and evidence of eosinophil-mediated organ damage. We report a case of a 55-year-old African American male with symptoms of heart failure. Hematology showed white blood cell count of 17 670/mm(3) with 63% eosinophils and an absolute eosinophil count of 11 133/mm(3) . Echocardiogram and computed tomography showed near complete obliteration of right ventricular cavity. Endomyocardial biopsy showed diffuse myocyte necrosis with extensive eosinophilic infiltration without fibrosis consistent with early Loeffler's endocarditis. Molecular and cytogenetic analyses of bone marrow cells were negative for FIP1L1-PDGFRA fusion, PDGFRB mutation, abnormal myeloid maturation, or a lymphoproliferative disorder. Flow cytometry showed no clonality excluding chronic eosinophilic leukemia. There was a complete resolution of symptoms and eosinophilia after 1 month of steroid therapy. |
| Databáze: | OpenAIRE |
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