Lack of association of statin use with Vitamin D levels in a hospital based population of type 2 diabetes mellitus patients
| Autor: | Iqbal Azam, Khalida Iqbal, Naseema Mehboobali, Najmul Islam, Mohammad Perwaiz Iqbal |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Statin medicine.drug_class Population Diabetes mellitus Vitamin D levels 0404 agricultural biotechnology Internal medicine medicine Vitamin D and neurology education education.field_of_study business.industry Statins Pakistani population nutritional and metabolic diseases Type 2 Diabetes Mellitus 04 agricultural and veterinary sciences General Medicine Hospital based Statin treatment medicine.disease 040401 food science Standard error Original Article lipids (amino acids peptides and proteins) business |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X |
| Popis: | Objective: To investigate the relationship of statins (drug given to reduce serum levels of LDL-cholesterol) on vitamin D levels of Pakistani type 2 diabetes mellitus (DM) patients in a hospital in Karachi. Methods: In a cross-sectional survey, 312 consecutive patients with type 2 DM (219 males and 93 females, age 22-70 years) were recruited with informed consent. A questionnaire was administered to find out whether they were statin users or non-users. Serum was analyzed for concentrations of 25(OH) vitamin D [25(OH)D] and other related biomarkers such as serum cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, phosphate and calcium using kit methods. Multiple Linear Regression was used to evaluate association of statin use with serum levels of vitamin D while adjusting for related covariates including duration of statin use, duration of type 2 DM and smoking. Results: Mean concentrations of serum cholesterol, and LDL-cholesterol were lower among statin users compared to statin non-users (P < 0.01), while HDL-cholesterol levels were higher (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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