Experimental Epidemiology of Antibiotic Resistance: Looking for an Appropriate Animal Model System
| Autor: | Llop, Pablo, Latorre, Amparo, Moya, Andrés |
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| Rok vydání: | 2019 |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The problem of antibiotic resistance in hospital bacteria and the human community has been recognized by various organizations as one of the greatest challenges to public health, which calls into question the maintenance and progress of modern medicine. This alarm is based on the inability to treat and prevent infections caused by microorganisms that are resistant to all therapeutic alternatives available. In recent years, there have been some unexpected circumstances that have acted synergistically and have worsened the problem, namely, (i) a general failure to discover new antimicrobials; (ii) the exponential development of antibiotic resistance in overcrowded countries with serious health deficits and the global spread of multiresistant bacteria; (iii) the invasion by resistant bacteria of ecosystems (surface water and sewage, soil, animals, and food) and, particularly, the invasion of human intestinal microbiota; and (iv) a pollution environment with high concentrations of antibiotics, metals, and biocides that favor the selection of multiresistant bacteria and their persistence. An estimated 25,000 people die each year in Europe and the United States from antibiotic resistance. |
| Databáze: | OpenAIRE |
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