Three Cases of Macroprolactinaemia
| Autor: | J W Kane, Adebayo Olukoga, Tim Dornan |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Hirsutism 030213 general clinical medicine medicine.medical_specialty endocrine system diseases Adenoma Physiology 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Menstruation Disturbances Pituitary microadenoma Prolactinoma hirsutism Macroprolactinaemia business.industry Hyperprolactinaemia General Medicine medicine.disease Bromocriptine Hyperprolactinemia Endocrinology Female business Research Article Hormone medicine.drug |
| Zdroj: | Journal of the Royal Society of Medicine. 92:342-344 |
| ISSN: | 1758-1095 0141-0768 |
| DOI: | 10.1177/014107689909200704 |
| Popis: | A woman with hirsutism but otherwise symptom-free was found to have a raised serum prolactin and a pituitary microadenoma. The hyperprolactinaemia persisted despite bromocriptine therapy and subsequent pituitary surgery, which yielded a non-functioning adenoma. After a further 15 years with persistent hyperprolactinaemia but no symptoms, macroprolactinaemia was diagnosed. Such cases might account for part of the failure rate of pituitary microsurgery for prolactinoma. Testing for macroprolactinaemia is advisable in a woman with hyperprolactinaemia, especially if her ovulatory cycle is normal. Two other cases are reported in which macroprolactinaemia was associated with menstrual disturbances and other hormonal effects: in these, treatment with dopamine agonists suppressed the hyperprolactinaemia and restored normal menstrual cycles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|