Clinical relevance of trace element measurement in patients on initiation of parenteral nutrition
| Autor: | Roy Sherwood, Kishor B. Raja, Royce P Vincent, Sohail Omar, Rashim Salota |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Parenteral Nutrition medicine.medical_specialty Clinical Biochemistry Serum albumin Nutritional Status chemistry.chemical_element 030209 endocrinology & metabolism Gastroenterology Selenium 03 medical and health sciences 0302 clinical medicine Malabsorption Syndromes Internal medicine medicine Humans Clinical significance In patient Intestinal Mucosa Serum Albumin Aged Retrospective Studies 030109 nutrition & dietetics biology business.industry C-reactive protein Acute-phase protein Albumin General Medicine Middle Aged Trace Elements Surgery Intestines Zinc C-Reactive Protein Parenteral nutrition chemistry biology.protein Female business Copper |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 53:680-685 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/0004563216633489 |
| Popis: | Background and Aims Serum zinc, copper and selenium are measured in patients prior to commencing on parenteral nutrition; however, their interpretation can be difficult due to acute phase reactions. We assessed (i) the relationship of raised C-reactive protein with trace elements and albumin (ii) benefits of measuring trace elements when C-reactive protein is raised in patients requiring short-term parenteral nutrition. Methods Samples were collected for zinc, copper, selenium and albumin at baseline and then every two weeks and correlated with C-reactive protein results in patients on parenteral nutrition. Results were categorized into four groups based on the C-reactive protein concentrations: (i) Results In 166 patients, zinc, selenium and albumin correlated (Spearman’s) negatively with C-reactive protein; r = −0.26, P 0.05), whereas selenium and albumin were lower in the group with C-reactive protein > 40 mg/L ( P Conclusion In patients on short-term parenteral nutrition, measurement of C-reactive protein is essential when interpreting zinc and selenium but not copper results. Routine measurement of trace elements prior to commencing parenteral nutrition has to be considered on an individual basis in patients with inflammation. |
| Databáze: | OpenAIRE |
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