Vancomycin Ophthalmic Ointment 1% for methicillin-resistantStaphylococcus aureusor methicillin-resistantStaphylococcus epidermidisinfections: a case series
| Autor: | Masahiko Fukuda, Yoshinori Saiki, Hideki Origasa, Masao Ohishi, Yoshikazu Shimomura, Keiko Yano, Chie Sotozono, Shigeru Kinoshita |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Microbiological culture Infections medicine.disease_cause Keratitis Staphylococcus epidermidis Internal medicine medicine Blepharitis biology business.industry Research Methicillin-resistant Staphylococcus epidermidis General Medicine medicine.disease biology.organism_classification Methicillin-resistant Staphylococcus aureus Surgery Ophthalmology Staphylococcus aureus Vancomycin business medicine.drug |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | Objectives To investigate the efficacy and safety of Vancomycin Ophthalmic Ointment 1% (Toa Pharmaceutical Co., Ltd, Toyama, Japan) in patients with external ocular infections caused by methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-resistant Staphylococcus epidermidis (MRSE). Design A case series. Setting This study was a multicentre, open-label, uncontrolled study in Japan approved as orphan drug status. Participants Patients with MRSA or MRSE external ocular infections unresponsive to the treatment of fluoroquinolone eye drops. Interventions Vancomycin Ophthalmic Ointment 1% was administered four times daily. Primary and secondary outcome measures The subjective and objective clinical scores and bacterial cultures were collected at days 0 (baseline), 3, 7 and 14. The primary outcome was clinical response evaluation (efficacy rate) determined as complete response , partial response , no response and worsening . Secondary outcome was the eradication of the bacteria. Safety was assessed by adverse events including cases in which neither MRSA nor MRSE was detected. Results Twenty-five cases with MRSA (20) or MRSE (5) infections were enrolled. Of these 25 cases, 4 discontinued the treatment due to the negative results for bacterial culture during screening or at baseline. Of the 21 cases with conjunctivitis (14), blepharitis (3), meibomitis (1), dacryocystitis (2) or keratitis (1), 14 (66.7%) cases were evaluated as being excellently ( complete response , 2 cases) or well ( partial response , 12 cases) treated. The eradication rates were 68.4% in MRSA (13 of 19 cases) and 100% in MRSE (2 of 2 cases). Ten adverse events occurred in 7 (28.0%) of 25 cases at the local administration site. Conclusions Vancomycin Ophthalmic Ointment 1% was considered to be useful for the treatment of intractable ocular MRSA/MRSE infections. |
| Databáze: | OpenAIRE |
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