Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells
| Autor: | Giovanni Mariggi, Marsha Wills-Karp, Richard A. Lang, Ian P. Lewkowich, Sujata Rao, Bart O. Williams, Terry P. Yamaguchi, Jeffrey W. Pollard, April C. Carpenter, Adam R. Burr, Jieqing Fan, James A. Stefater, Napoleone Ferrara, Holger Gerhardt, Jeffery D. Molkentin, Rieko Ajima |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Somatic cell Angiogenesis Neovascularization Physiologic Biology Ligands Retina Wnt-5a Protein Article Receptors G-Protein-Coupled Neovascularization Mice chemistry.chemical_compound Internal medicine medicine Animals Myeloid Cells General LDL-Receptor Related Proteins Vascular Endothelial Growth Factor Receptor-1 Multidisciplinary Intracellular Signaling Peptides and Proteins Wnt signaling pathway Endothelial Cells Fibroblasts Cell biology Wnt Proteins WNT5A Vascular endothelial growth factor Low Density Lipoprotein Receptor-Related Protein-5 Endocrinology medicine.anatomical_structure chemistry Blood Vessels Signal transduction medicine.symptom Signal Transduction |
| Zdroj: | Stefater, J A, Lewkowich, I, Rao, S, Mariggi, G, Carpenter, A C, Burr, A R, Fan, J, Ajima, R, Molkentin, J D, Williams, B O, Wills-Karp, M, Pollard, J W, Yamaguchi, T, Ferrara, N, Gerhardt, H & Lang, R A 2011, ' Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells ', Nature, vol. 474, no. 7352, pp. 511-5 . https://doi.org/10.1038/nature10085 Nature |
| DOI: | 10.1038/nature10085 |
| Popis: | Myeloid cells are a feature of most tissues. Here we show that during development, retinal myeloid cells (RMCs) produce Wnt ligands to regulate blood vessel branching. In the mouse retina, where angiogenesis occurs postnatally1, somatic deletion in RMCs of the Wnt ligand transporter Wntless2,3 results in increased angiogenesis in the deeper layers. We also show that mutation of Wnt5a and Wnt11 results in increased angiogenesis and that these ligands elicit RMC responses via a non-canonical Wnt pathway. Using cultured myeloid-like cells and RMC somatic deletion of Flt1, we show that an effector of Wnt-dependent suppression of angiogenesis by RMCs is Flt1, a naturally occurring inhibitor of vascular endothelial growth factor (VEGF)4-6. These findings indicate that resident myeloid cells can use a non-canonical, Wnt-Flt1 pathway to suppress angiogenic branching. |
| Databáze: | OpenAIRE |
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