Sustained Release Systems for Delivery of Therapeutic Peptide/Protein
| Autor: | Wei Wang, Tianqi Nie, Xiaohu Liu, Xinyu Song, Jingwen Zhang, Yanan Wang, Liangmin Yu, Keyang Li, Zhiyu He |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Polymers and Plastics
Bioengineering Peptide 02 engineering and technology Pharmacology Initial burst 010402 general chemistry 01 natural sciences Biomaterials Drug Delivery Systems Materials Chemistry Humans Medicine Patient compliance Clinical treatment chemistry.chemical_classification Protein therapeutics business.industry Immunogenicity Proteins 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Delayed-Action Preparations Peptides 0210 nano-technology business Enzyme degradation Half-Life Clearance |
| Zdroj: | Biomacromolecules. 22:2299-2324 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.1c00160 |
| Popis: | Peptide/protein therapeutics have been significantly applied in the clinical treatment of various diseases such as cancer, diabetes, etc. owing to their high biocompatibility, specificity, and therapeutic efficacy. However, due to their immunogenicity, instability stemming from its complex tertiary and quaternary structure, vulnerability to enzyme degradation, and rapid renal clearance, the clinical application of protein/peptide therapeutics is significantly confined. Though nanotechnology has been demonstrated to prevent enzyme degradation of the protein therapeutics and thus enhance the half-life, issues such as initial burst release and uncontrollable release kinetics are still unsolved. Moreover, the traditional administration method results in poor patient compliance, limiting the clinical application of protein/peptide therapeutics. Exploiting the sustained-release formulations for more controllable delivery of protein/peptide therapeutics to decrease the frequency of injection and enhance patient compliance is thus greatly meaningful. In this review, we comprehensively summarize the substantial advancements of protein/peptide sustained-release systems in the past decades. In addition, the advantages and disadvantages of all these sustained-release systems in clinical application together with their future challenges are also discussed in this review. |
| Databáze: | OpenAIRE |
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