| Autor: |
Manuel van Gijsel-Bonnello, Nicola J. Darling, Takashi Tanaka, Samuele Di Carmine, Francesco Marchesi, Sarah Thomson, Kristopher Clark, Mariola Kurowska-Stolarska, Henry J. McSorley, Philip Cohen, J. Simon C. Arthur |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Biological Chemistry. 298:102644 |
| ISSN: |
0021-9258 |
| Popis: |
Idiopathic pulmonary fibrosis is a progressive and normally fatal disease with limited treatment options. The tyrosine kinase inhibitor nintedanib has recently been approved for the treatment of idiopathic pulmonary fibrosis, and its effectiveness has been linked to its ability to inhibit a number of receptor tyrosine kinases including the platelet-derived growth factor, vascular endothelial growth factor, and fibroblast growth factor receptors. We show here that nintedanib also inhibits salt-inducible kinase 2 (SIK2), with a similar IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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