The influence of blood transfusion on survival in operated non–small cell lung cancer patients
| Autor: | Jan Skokowski, Artur Raiter, Amelia Szymanowska, Rafal Dziadziuszko, Radoslaw Wilimski, Witold Rzyman, Jacek Jassem |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Blood transfusion medicine.medical_treatment Gastroenterology Pneumonectomy Blood product Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans Blood Transfusion Lung cancer Survival rate Survival analysis Aged Retrospective Studies Univariate analysis business.industry Cancer Middle Aged Prognosis medicine.disease Surgery Survival Rate Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 126:755-760 |
| ISSN: | 0022-5223 |
| Popis: | Background It has been postulated that allogeneic transfusions have immunosuppressive effects that can promote tumor growth and metastasis formation. Despite the variety of publications on this controversial topic, the influence of blood transfusion on survival is not yet clearly identified. The impact of autologous blood transfusion on survival has only occasionally been analyzed in cancer patients. Objective To determine the effect of perioperative allogeneic and autologous blood transfusions on survival in non–small cell lung cancer patients treated with curative pulmonary resection. Methods Of 493 consecutive patients, 185 (37.5%) received allogeneic blood products and 145 (29.4%) received autologous blood products, whereas 163 patients (33.1%) received no blood products. Survival analysis included univariate log-rank test and multivariate Cox regression model. Results Three-year survival probabilities in allogeneic, autologous, and nontransfused groups were 40%, 48%, and 61%, respectively, and the estimated 5-year survival probabilities were 34%, 38%, and 48%, respectively. In the univariate analysis there was a reduced survival in allogeneic versus nontransfused group ( P P P = .01) and sedimentation rate ( P = .03) remained significant factors, whereas the type of blood transfusion (allogeneic versus autologous) was no longer significant. There was no significant impact of transfusion in the multivariate analysis when patients in stage III or patients who underwent pneumonectomy were excluded. Conclusion Neither allogeneic nor autologous blood transfusion has independent, adverse survival impact in non–small cell lung cancer patients treated with radical pulmonary resection. |
| Databáze: | OpenAIRE |
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