Maternal environment defines blood pressure and its response to troleandomycin in spontaneously hypertensive rats
| Autor: | S Ghosh, Charles O. Watlington, Walter E. Nance, L. B. Kramer, Rodney D. Hagley, Ashish K. Basu |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Offspring Blood Pressure Environment Rats Inbred WKY Troleandomycin Epistatic interaction Spontaneously hypertensive rat Cytochrome P-450 Enzyme System Species Specificity Rats Inbred SHR Internal medicine Internal Medicine medicine Animals cardiovascular diseases Maternal Behavior business.industry Strain difference musculoskeletal system Rats Endocrinology Blood pressure Animals Newborn Hypertension cardiovascular system Female business circulatory and respiratory physiology medicine.drug |
| Zdroj: | American Journal of Hypertension. 8:321-324 |
| ISSN: | 0895-7061 |
| DOI: | 10.1016/0895-7061(94)00198-k |
| Popis: | Relationship between family-3A cytochrome P-450-dependent (troleandomycin inhibitable) and maternal environmental-dependent systolic blood pressure (SBP) was investigated in spontaneously hypertensive rats (SHR). Adult SHR nursed by foster or natural SHR mothers had indistinguishable SBP. Troleandomycin reduced 50% of Wistar-Kyoto (WKY)-SHR strain difference in SBP. SHR having WKY foster mothers had SBP similar to troleandomycin-reduced SHR levels, which was unaffected by troleandomycin. The two components of SBP elevation appear identical. Because observations of others demonstrated that WKY fostered to SHR show no SBP increase, the maternally dependent/troleandomycin-sensitive component of SBP elevation may reflect epistatic interaction between genes determining maternal differences and offspring sensitivity, respectively. |
| Databáze: | OpenAIRE |
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