Self-controlled Study of Onychomycosis Treated with Long-pulsed Nd
| Autor: | Jing Xu, Jun Ying Zhao, Feng Lin Zhuo, Yan Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Antifungal Agents Adolescent Itraconazole Laser Treatment Nd-YAG Laser Onychomycosis lcsh:Medicine Lasers Solid-State Gastroenterology Group B Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Laser therapy Disease severity Oral administration Internal medicine medicine Humans Aged business.industry Laser treatment lcsh:R Therapeutic effect General Medicine Middle Aged Combined Modality Therapy Surgery Treatment Outcome 030220 oncology & carcinogenesis Nd:YAG laser Female Original Article Laser Therapy business medicine.drug |
| Zdroj: | Chinese Medical Journal, Vol 129, Iss 16, Pp 1929-1934 (2016) Chinese Medical Journal |
| ISSN: | 0366-6999 |
| Popis: | Background: Onychomycosis is a fungal infection of the nail plate and subungual area. In this study, we examined the efficacy of laser treatment using self-controlled study programs involving a long-pulsed Nd:YAG 1064-nm laser combined with oral medication. Methods: Self-controlled strategies were followed in this study. The patients received treatment with oral itraconazole in conjunction with long-pulsed Nd:YAG 1064-nm laser treatment at the nails of the unilateral limb once a week for a total of four times. A total of 84 affected nails were divided into Group A (mild to moderate) and Group B (severe) according to disease severity. Affected nails with the same Scoring Clinical Index for Onychomycosis scores were selected to compare the therapeutic effects of the pure medication treatment group and the combination treatment group with a 24-week follow-up period. Results: In Group A, at the 8 th , 16 th , and 24 th weeks of follow-up, the efficacies in the pure medication treatment group were 81.0%, 81.0%, and 90.5%, respectively, while those in the combination treatment group were 100%, 95.2%, and 90.5%, respectively. The differences between groups were not significant (8 th week: χ 2 = 4.421, P > 0.05; 16 th week: χ 2 = 2.043, P > 0.05; 24 th week: χ 2 = 0.00, P > 0.05). In Group B, at the 8 th , 16 th , and 24 th weeks of follow-up, the efficacies in the pure medication treatment group were 61.9%, 66.7%, and 52.4%, respectively, while those in the combination treatment group were 95.2%, 90.5%, and 100%, respectively. The differences between groups at the 8 th and 24 th weeks of follow-up were statistically significant (8 th week: χ 2 = 6.929, P th week: χ 2 = 13.125, P Conclusions: For patients with mild or moderate onychomycosis, we recommended a pure medication treatment or combination treatment with medication and laser. For those patients with severe onychomycosis, we recommended a combination of medication and laser therapy. |
| Databáze: | OpenAIRE |
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