The development of preeclampsia in oocyte donation pregnancies is related to the number of fetal-maternal HLA class II mismatches
| Autor: | K. van Bentem, Sebastiaan Heidt, C. van der Keur, M.L.P. van der Hoorn, Manon Bos, Dave L. Roelen, Eileen E L O Lashley, F.H.J. Claas, Simone H. Brand-Schaaf, Michael Eikmans, Geert W. Haasnoot |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Fetal-maternal HLA mismatches Umbilical cord 0302 clinical medicine Pre-Eclampsia Isoantibodies Pregnancy Risk Factors Immunology and Allergy Maternal-Fetal Exchange Immunity Cellular 030219 obstetrics & reproductive medicine Oocyte Donation biology Incidence Obstetrics and Gynecology Oocyte donation pregnancy Middle Aged Fetal Blood medicine.anatomical_structure Cohort Female Antibody Adult Immunology Fertilization in Vitro Human leukocyte antigen Immunophenotyping Preeclampsia 03 medical and health sciences Fetus HLA-DQ Antigens Immune Tolerance medicine Humans Risk factor Retrospective Studies business.industry HLA-DR Antigens medicine.disease 030104 developmental biology Reproductive Medicine Case-Control Studies Immunoglobulin G biology.protein business |
| Zdroj: | Journal of Reproductive Immunology, 137. ELSEVIER IRELAND LTD |
| Popis: | In oocyte donation (OD) pregnancy, a fetus can be completely allogeneic to the recipient. Consequently, the maternal immune system has to cope with greater immunogenetic dissimilarity compared to naturally conceived pregnancy. Previously, we showed an association between successful OD pregnancy and lower immunogenetic dissimilarity, reflected by the number of fetal-maternal Human Leukocyte Antigen (HLA) mismatches, than expected by chance. In this study we aimed to determine whether the development of preeclampsia in OD pregnancies is related to the number of fetal-maternal HLA mismatches. A retrospective, nested case-control study was performed within a cohort of 76 singleton OD pregnancies. Maternal and fetal umbilical cord blood was typed for HLA-A, -B, -C, -DR and -DQ, and the number of fetal-maternal HLA mismatches was calculated. In addition, the incidence of child-specific HLA antibodies was determined. 13 pregnancies were complicated by preeclampsia. To demonstrate an influence of HLA mismatches on the development of preeclampsia, a univariate logistic regression analysis was performed adjusted for maternal age and socio-economic status. A significant association between the number of fetal-maternal HLA class II mismatches and the development of preeclampsia was observed (OR = 3.8, 95 % CI: 1.6–9.0; p = 0.003). This association was not linked to the development of HLA class II antibodies. According to our findings, an increased number of HLA class II mismatches is a risk factor for the development of preeclampsia in OD pregnancies. The effect of HLA class II mismatches might be explained by the induction of a cellular rather than a humoral immune response. |
| Databáze: | OpenAIRE |
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