Alleviative effects of deep-seawater drinking water on hepatic lipid accumulation and oxidation induced by a high-fat diet
| Autor: | Yi-Chen Chen, Jr-Wei Chen, Yuan-Yen Chang, Ming-Hsu Chang, I-Shu Chen, Chin-Lin Hsu, Sheng-Shih Chen, Hui-Wen Lin |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty H&E stain Diet High-Fat Liver disease chemistry.chemical_compound nonalcoholic hepatosteatosis Internal medicine Cricetinae Malondialdehyde medicine Animals Seawater Medicine(all) lcsh:R5-920 Triglyceride liver lipid peroxidation Mesocricetus business.industry Drinking Water Lipid metabolism General Medicine medicine.disease Lipid Metabolism Glutathione lipid homeostasis Endocrinology chemistry Distilled water Liver deep-seawater drinking water Steatosis business lcsh:Medicine (General) Oxidation-Reduction Homeostasis |
| Zdroj: | Journal of the Chinese Medical Association, Vol 76, Iss 2, Pp 95-101 (2013) |
| ISSN: | 1726-4901 |
| DOI: | 10.1016/j.jcma.2012.10.008 |
| Popis: | Background: Hepatic steatosis is defined as excessive amounts of triglyceride and other fats inside liver cells and has become an emergent liver disease in developed and developing countries. Methods: Deep seawater (DSW)300, DSW900, and DSW1500 drinking waters were formulated via a combination of reverse osmosis and electrodialysis. Hamsters on a high-fat diet were assigned to drink the following solutions: (1) normal distilled water, (2) DSW300, (3) DSW900, or (4) DSW1500. Serum, liver, and fecal biochemical values, expression of hepatic genes related to fatty-acid homeostasis, as well as liver antioxidative levels were measured after a 6-week feeding period. Additionally, hematoxylin and eosin staining was used to investigate the liver histopathology. Results: Serum/liver lipids, liver sizes, liver malondialdehyde content, and serum aspartate aminotransferase and alanine aminotransferase of high-fat diet hamsters were reduced (p 0.05) altered, DSW drinking water upregulated (p |
| Databáze: | OpenAIRE |
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