Presence of fibronectin-binding protein gene prtF2 in invasive group A streptococci in tropical Australia is associated with increased internalisation efficiency
| Autor: | Ramon Layton, Davina Gorton, Robert Norton, Helen V. Smith, Natkunam Ketheesan |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
biology
Streptococcus pyogenes Binding protein Immunology Molecular Sequence Data Australia Virulence biology.organism_classification Streptococcaceae medicine.disease_cause Microbiology Group A Infectious Diseases Fibronectin binding Streptococcal Infections medicine Humans Amino Acid Sequence Adhesins Bacterial Gene Sequence Alignment Bacteria |
| Zdroj: | Microbes and infection. 7(3) |
| ISSN: | 1286-4579 |
| Popis: | The fibronectin-binding proteins (FnBPs) PrtF1 and PrtF2 are considered to be major group A streptococcal virulence factors, mediating adherence to and internalisation of host cells. The present study investigated an association between the presence of prtF1 and prtF2 genes and internalisation efficiency in group A streptococci (GAS) isolated from patients with invasive disease. Of the 80 isolates tested, 58 (73%) had prtF1 and 71 (89%) possessed prtF2. Three isolates (4%) had neither gene, seven (9%) had prtF1 only, 19 (24%) had prtF2 only and 51 isolates (64%) had both prtF1 and prtF2. prtF2-positive isolates internalised up to three times more efficiently than isolates that had prtF1 alone (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect