Kardiale stereotaktische Strahlentherapie induziert eine Umprogrammierung des elektrischen Reizleitungssystems
| Autor: | Oliver Blanck, Judit Boda-Heggemann, Stephan Hohmann, Felix Mehrhof, David Krug |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Action Potentials Dose-Response Relationship Radiation Heart Endomyocardial Fibrosis NAV1.5 Voltage-Gated Sodium Channel Electrocardiography Mice Oncology Gene Expression Regulation Heart Conduction System Heart Rate Connexin 43 Tachycardia Ventricular Animals Humans Radiology Nuclear Medicine and imaging Female Radiotherapy Literatur Kommentiert Signal Transduction |
| Zdroj: | Strahlentherapie Und Onkologie |
| ISSN: | 1439-099X 0179-7158 |
| Popis: | Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude with which VT reduction occurs clinically. Here, we demonstrate in hearts from RT patients that radiation does not achieve transmural fibrosis within the timeframe of VT reduction. Electrophysiologic assessment of irradiated murine hearts reveals a persistent supraphysiologic electrical phenotype, mediated by increases in Na |
| Databáze: | OpenAIRE |
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