Hyperintense acute reperfusion marker on FLAIR is not associated with early haemorrhagic transformation in the elderly
| Autor: | Michal Rozanski, Jochen B. Fiebach, Benjamin Hotter, Martin Ebinger, Wolf U. Schmidt, Peter U. Heuschmann, Jan G. Jungehuelsing, Sandra Pittl |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Fluid-attenuated inversion recovery Blood–brain barrier Sensitivity and Specificity Internal medicine Ischaemic stroke medicine Humans Radiology Nuclear Medicine and imaging Recombinant tissue plasminogen activator Neuroradiology Cerebral Hemorrhage Aged 80 and over medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging Interventional radiology General Medicine Thrombolysis Magnetic Resonance Imaging Surgery medicine.anatomical_structure Ischemic Attack Transient Reperfusion Injury Cardiology Female Radiology business |
| Zdroj: | European radiology. 20(12) |
| ISSN: | 1432-1084 |
| Popis: | The hyperintense acute reperfusion marker (HARM) has been described as a predictor for haemorrhagic transformation (HT) in acute ischaemic stroke. We hypothesised that this phenomenon is not present in the elderly. It was possible to assess 47/84 consecutive patients aged 80 and over with diagnosed ischaemic stroke or transient ischaemic attack (TIA). MRI was performed within 24 h of onset of symptoms with follow-up MRI within a further 48 h. Of 47 included patients, 19 showed HARM; it was only seen on follow-up examination. Ten of the 47 patients underwent thrombolysis with recombinant tissue plasminogen activator (rt-PA); 4 of them showed HARM, and 1 of those showed HT. HARM was found in three out of eight patients with haemorrhagic transformation on baseline and/or follow-up MRI. We did not observe an association between HARM and early HT either in the whole group or in the patients who received thrombolysis. HARM was not associated with HT in the elderly after ischaemic stroke, independent of treatment. While it may indicate dysfunction of the blood-brain barrier (BBB), it does not necessarily amount to HT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink