MASPIN subcellular localization and expression in oral cavity squamous cell carcinoma
| Autor: | Emiliano D'Alessandro, Elisa Facco, Gino Marioni, Stella Blandamura, Andy Bertolin, Roberto Stramare, Elena Gaio, Luciano Giacomelli, Alberto Staffieri |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Palate Hard Cytoplasm Pathology medicine.medical_specialty Angiogenesis Biology Metastasis Carcinoma medicine Humans Oral Cavity Squamous Cell Carcinoma Serpins Aged Aged 80 and over Cell Nucleus Palatal Neoplasms Mouth Mucosa Maspin Cancer General Medicine Middle Aged Prognosis medicine.disease Subcellular localization Immunohistochemistry Tongue Neoplasms Cheek Otorhinolaryngology Lip Neoplasms Carcinoma Squamous Cell Female Mouth Neoplasms Neoplasm Recurrence Local Subcellular Fractions |
| Zdroj: | European Archives of Oto-Rhino-Laryngology. 265:97-104 |
| ISSN: | 1434-4726 0937-4477 |
| Popis: | MASPIN, a member of serpin superfamily, has multifaceted biological functions and an unique tumour suppressing activity. Experimental evidences showed that MASPIN suppresses tumour growth, angiogenesis, invasion and metastasis. Only a very limited number of studies considered MASPIN expression in the upper aero-digestive tract carcinomas. It was recently found that nuclear localization of MASPIN was significantly associated with lower recurrence rate and longer disease-free interval in laryngeal carcinoma. The present study investigated the biological and prognostic role of MASPIN in relation to its subcellular localization in oral carcinoma. Sub-cellular pattern of distribution of MASPIN, nuclear and cytoplasmic MASPIN expressions were immunohistochemically determined in 56 consecutive cases of oral carcinoma. Statistical analysis found a significant association between pN-stage and recurrence of disease (P = 0.032) and a significantly longer disease-free interval in pN0 patients than in pN+ ones (P = 0.038). None of the subcellular expressions of MASPIN was significantly correlated with recurrence of disease and disease-free interval in our series of oral carcinomas. Sixty-one percent of pN0 cases was strongly MASPIN-positive in the cytoplasm of primary carcinoma cells, 33% of the pN+ cases was MASPIN-positive in the cytoplasm. Statistical analysis found a significant association between MASPIN cytoplasmic expression and pN-stage (P = 0.032). Negative MASPIN immunoreactivity in carcinoma cells cytoplasm may be useful to identify patients at risk of disease disseminating to neck lymph nodes. Further investigations are necessary to understand the biological role of cytoplasmic MASPIN localization in oral carcinoma. |
| Databáze: | OpenAIRE |
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