New Strategies in Ovarian Cancer: Uptake and Experience of Women at High Risk of Ovarian Cancer Who Are Considering Risk-Reducing Salpingo-Oophorectomy
| Autor: | Mary B. Daly, Pagona Roussi, Suzanne M. Miller, John Scarpato |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
medicine.medical_specialty Hormone Replacement Therapy Ovariectomy medicine.medical_treatment Decision Making Medical Oncology Choice Behavior Article Breast cancer Patient Education as Topic Risk Factors medicine Humans Medical history Risk factor Salpingostomy Ovarian Neoplasms Gynecology Obstetrics business.industry Carcinoma Cancer Prophylactic Mastectomy Hormone replacement therapy (menopause) medicine.disease Oncology Female Ovarian cancer business Risk Reduction Behavior Psychosocial |
| Zdroj: | Clinical Cancer Research. 16:5094-5106 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-09-2953 |
| Popis: | Here, we review factors associated with uptake of risk-reducing salpingo-oophorectomy by women at increased hereditary risk for ovarian cancer, as well as quality of life issues following surgery. Forty-one research studies identified through PubMed and PsychInfo met inclusion criteria. Older age, having had children, a family history of ovarian cancer, a personal history of breast cancer, prophylactic mastectomy, and BRCA1/2 mutation carrier status increase the likelihood of undergoing surgery. Psychosocial variables predictive of surgery uptake include greater perceived risk of ovarian cancer and cancer-related anxiety. Most women report satisfaction with their decision to undergo surgery and both lower perceived ovarian cancer risk and less cancer-related anxiety as benefits. Hormonal deprivation is the main disadvantage reported, particularly by premenopausal women who are not on hormonal replacement therapy (HRT). The evidence is mixed about satisfaction with the level of information provided prior to surgery, although generally, women report receiving insufficient information about the pros and cons of HRT. These findings indicate that when designing decision aids, demographic, medical history, and psychosocial variables need to be addressed in order to facilitate quality decision making. Clin Cancer Res; 16(21); 5094–106. ©2010 AACR. |
| Databáze: | OpenAIRE |
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