Intracardiac impedance response during acute AF internal cardioversion using novel rectilinear and capacitor-discharge waveforms
| Autor: | PR Walsh, Simon J Walsh, Ganesh Manoharan, Omar J. Escalona, A. S. Rababah |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Physiology Defibrillation medicine.medical_treatment Electric Countershock Biomedical Engineering Biophysics 030204 cardiovascular system & hematology Cardioversion Impedance parameters Intracardiac injection 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Electric Impedance medicine Animals Waveform Heart Atria Electrical impedance Sheep Domestic Retrospective Studies business.industry Models Cardiovascular Atrial fibrillation Atrial Function medicine.disease Cardiology business Algorithms Software 030217 neurology & neurosurgery Energy (signal processing) |
| Zdroj: | Physiological Measurement. 37:1129-1145 |
| ISSN: | 1361-6579 0967-3334 |
| DOI: | 10.1088/0967-3334/37/7/1129 |
| Popis: | Intracardiac impedance (ICI) is a major determinant of success during internal cardioversion of atrial fibrillation (AF). However, there have been few studies that have examined the dynamic behaviour of atrial impedance during internal cardioversion in relation to clinical outcome. In this study, voltage and current waveforms captured during internal cardioversion of acute AF in ovine models using novel radiofrequency (RF) generated low-tilt rectilinear and conventional capacitor-discharge based shock waveforms were retrospectively analysed using a digital signal processing algorithm to investigate the dynamic behaviour of atrial impedance during cardioversion. The algorithm was specifically designed to facilitate the simultaneous analysis of multiple impedance parameters, including: mean intracardiac impedance (Z M), intracardiac impedance variance (ICIV) and impedance amplitude spectrum area (IAMSA) for each cardioversion event. A significant reduction in ICI was observed when comparing two successive shocks of increasing energy where cardioversion outcome was successful. In addition, ICIV and IAMSA variables were found to inversely correlate to the magnitude of energy delivered; with a stronger correlation found to the former parameter. In conclusion, ICIV and IAMSA have been evidenced as two key dynamic intracardiac impedance variables that may prove useful in better understanding of the cardioversion process and that could potentially act as prognostic markers with respect to clinical outcome. |
| Databáze: | OpenAIRE |
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