N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity

Autor:	Theresa M. Williams, Jeffrey M. Bergman, Karen Brashear, Michael J. Breslin, Christopher J. Dinsmore, John H. Hutchinson, Suzanne C. MacTough, Craig A. Stump, Donna D. Wei, C. Blair Zartman, Michael J. Bogusky, J. Christopher Culberson, Carolyn Buser-Doepner, Joseph Davide, Ian B. Greenberg, Kelly A. Hamilton, Kenneth S. Koblan, Nancy E. Kohl, Dongming Liu, Robert B. Lobell, Scott D. Mosser, Timothy J. O'Neill, Elaine Rands, Michael D. Schaber, Francine Wilson, Edith Senderak, Sherri L. Motzel, Jackson B. Gibbs, Samuel L. Graham, David C. Heimbrook, George D. Hartman, Allen I. Oliff, Joel R. Huff
Rok vydání:	1999
Předmět:	Models Molecular Farnesyltransferase Mice Nude Tumor cells Piperazines Mice Drug Discovery Tumor Cells Cultured Animals Farnesyltranstransferase Humans Enzyme Inhibitors chemistry.chemical_classification Farnesyl-diphosphate farnesyltransferase Alkyl and Aryl Transferases biology Chemistry Imidazoles Biological activity In vitro Rats Enzyme Biochemistry Enzyme inhibitor Benzene derivatives biology.protein Molecular Medicine
Zdroj:	Journal of medicinal chemistry. 42(19)
ISSN:	0022-2623
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9aa6dfaa30c010acc003d699cbd1f8 https://pubmed.ncbi.nlm.nih.gov/10508426 Zobrazit plný text záznamu