Meta- and Para-Difunctionalization of Arenes via a Sulfoxide−Magnesium Exchange Reaction

Autor:	Laurin Melzig, Christian B. Rauhut, Paul Knochel
Rok vydání:	2008
Předmět:	Magnesium Metalation Aryl Organic Chemistry Leaving group Regioselectivity chemistry.chemical_element Sulfoxide Biochemistry chemistry.chemical_compound chemistry Group (periodic table) Moiety Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 10:3891-3894
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol801431z
Popis:	The aryl sulfoxide moiety (ArSO) allows an expedient two-step meta-, para-difunctionalization of readily available diaryl sulfoxides. In the first step, the sulfoxide plays the role of a directing metalation group. In the second step, triggered by i-PrMgCl x LiCl, it becomes a leaving group and undergoes a regioselective sulfoxide-magnesium exchange.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b99ae4a3faab41e625d75cdb30e4649 https://doi.org/10.1021/ol801431z Zobrazit plný text záznamu