Polymorphic Variation in Glutathione-S-transferase Genes and Risk of Chronic Myeloid Leukaemia in the Kashmiri Population
| Autor: | Samoon Jeelani, Bashir A. Ganai, Nida Sadiq, Aadil Wani, Rajinder Kaur, Akbar Masood, Gulzar Ahmad Bhat, Ashaqullah Bhat |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Epidemiology Population India Biology Logistic regression Gastroenterology Risk Factors Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Statistical significance Internal medicine Genotype Genetic predisposition medicine Humans Genetic Predisposition to Disease education neoplasms Gene Glutathione Transferase education.field_of_study Polymorphism Genetic Public Health Environmental and Occupational Health Cancer Prognosis medicine.disease Glutathione S-transferase Oncology Case-Control Studies Immunology biology.protein Female |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 13:69-73 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2012.13.1.069 |
| Popis: | Cancer is a complex disease and the genetic susceptibility to it could be an outcome of the inherited difference in the capacity of xenobiotic metabolizing enzymes. Glutathione-S-transferases (GSTs) are phase II metabolizing enzymes whose various genotypes have been associated with increased risk of different types of cancer. Null mutations caused by the deletion of the entire gene result in the absence of the enzymatic activity and increase in the risk of developing cancer including chronic myeloid leukaemia (CML). In the present case-control study we evaluated the effect of null mutations in GSTM1 and GSTT1 genes on the risk of developing CML. The study included 75 CML patients (43 males and 32 females; age (mean ± S.D) 42.3 ± 13.4 years) and unrelated non-malignant controls (76 male and 48 females; age (mean ± S.D) 41.5 ± 12.9). The distribution of GSTM1 and GSTT1 genotypes in CML patients and controls was assessed by multiplex-PCR method. Logistic regression was used to assess the relationship between GSTM1 and GSTT1 genotypes and risk of CML. Chi-square test was used to evaluate the trend in modulating the risk to CML by one or more potential high risk genotype. Although GSTM1 null genotype frequency was higher in CML patients (41%) than in the controls (35%), it did not reached a statistical significance (OD = 1.32, 95% CI: 0.73-2.40; P value = 0.4295). The frequency of GSTT1 null genotypes was higher in the CML patients (36%) than in the controls (21%) and the difference was found to be statistically significant (OD = 2.12, 95% CI: 1.12-4.02; P value = 0.0308). This suggests that the presence of GSTT1 genotype may have protective role against the CML. We found a statistically significant (OD = 3.09, 95% CI: 1.122-8.528; P value = 0.0472) interaction between the GSTM1 and GSTT1 null genotypes and thus individuals carrying null genotypes of both GSTM1 and GSTT1 genes are at elevated risk of CML. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|