Calcium and vitamin D for osteoprotection in children with new-onset nephrotic syndrome treated with steroids: a prospective, randomized, controlled, interventional study
| Autor: | Surabhi Choudhary, Mandalam S. Seshadri, Indira Agarwal |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
musculoskeletal diseases Nephrology medicine.medical_specialty Nephrotic Syndrome Prednisolone Elemental calcium chemistry.chemical_element Calcium Gastroenterology Bone and Bones law.invention Fractures Bone Absorptiometry Photon Randomized controlled trial Adrenal Cortex Hormones Bone Density law Internal medicine medicine Vitamin D and neurology Humans Single-Blind Method Vitamin D Child Bone mineral Bone Density Conservation Agents business.industry Infant musculoskeletal system medicine.disease Calcium Dietary Endocrinology chemistry Child Preschool Dietary Supplements Pediatrics Perinatology and Child Health Female business Nephrotic syndrome medicine.drug |
| Zdroj: | Pediatric Nephrology. 29:1025-1032 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-013-2720-4 |
| Popis: | There are no robust guidelines on strategies to prevent the adverse skeletal effects of glucocorticoids in children. To evaluate the role of prophylactic calcium and vitamin D on bone health in children with new-onset nephrotic syndrome (NS) treated with short-term (12 weeks), high-dose glucocorticoids. Prospective, randomized, controlled, single blind, interventional study conducted on 41 steroid-naive pre-pubertal children (29 boys, 12 girls). All children received prednisolone for 12 weeks (60 mg/m2/day daily for 6 weeks, followed by 40 mg/m2/day alternate days for 6 weeks). Recruited children were randomized into the intervention group (IG; vitamin D 1,000 IU/day and elemental calcium 500 mg/day) and the control group (CG). Bone mineral content (BMC) and bone mineral density (BMD) at the lumbar spine (L1–L4) were estimated at baseline and at 12 weeks. Mean percentage changes in BMC and BMD in IG and CG were compared. Children in the IG showed an increase of 11.2 % in BMC versus the CG, who showed an 8.9 % fall (p |
| Databáze: | OpenAIRE |
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