The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis
| Autor: | David Alvarez, Rohit Garg, Anthonie J. Zwijnenburg, Carmen Gerlach, Lisette Waanders, Juan Carlos de la Torre, Ulrich H. von Andrian, Scott Loughhead, E. Ashley Moseman |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Immunology CX3C Chemokine Receptor 1 Cell Separation CD8-Positive T-Lymphocytes Biology Mice 03 medical and health sciences Chemokine receptor 0302 clinical medicine Antigen T-Lymphocyte Subsets CX3CR1 Animals Homeostasis Immunology and Allergy Cytotoxic T cell Receptor Immunologic Surveillance Effector Flow Cytometry Phenotype Cell biology Mice Inbred C57BL 030104 developmental biology Infectious Diseases Receptors Chemokine Immunologic Memory CD8 030215 immunology |
| Zdroj: | Immunity. 45:1270-1284 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2016.10.018 |
| Popis: | Summary Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that underlie these transitions are poorly understood. Here, we found that the chemokine receptor CX3CR1 identifies three distinct CD8 + Teff and Tmem subsets. Classical central (Tcm) and effector memory (Tem) cells and their corresponding Teff precursors were CX3CR1 – and CX3CR1 high , respectively. Viral infection also induced a numerically stable CX3CR1 int subset that represented ∼15% of blood-borne Tmem cells. CX3CR1 int Tmem cells underwent more frequent homeostatic divisions than other Tmem subsets and not only self-renewed, but also contributed to the expanding CX3CR1 – Tcm pool. Both Tcm and CX3CR1 int cells homed to lymph nodes, but CX3CR1 int cells, and not Tem cells, predominantly surveyed peripheral tissues. As CX3CR1 int Tmem cells present unique phenotypic, homeostatic, and migratory properties, we designate this subset peripheral memory (tpm) cells and propose that tpm cells are chiefly responsible for the global surveillance of non-lymphoid tissues. |
| Databáze: | OpenAIRE |
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