Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
| Autor: | Ricardo Ribeiro dos Santos, Jorge Andion Torreão, Luis C. L. Correia, Milena Botelho Pereira Soares, Bruno Solano de Freitas Souza, Alessandra Carvalho Caldas, Márcia Noya-Rabelo, Moisés Imbassahy Guimarães Moreira, Ticiana Ferreira Larocca |
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| Rok vydání: | 2015 |
| Předmět: |
Chagas disease
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Longitudinal global strain Cardiac & Cardiovascular Systems Ejection fraction business.industry Speckle tracking strain Area under the curve medicine.disease Predictive value Article Speckle pattern lcsh:RC666-701 Internal medicine medicine Cardiology Myocardial fibrosis Myocardial infarction Cardiology and Cardiovascular Medicine business Speckle tracking |
| Zdroj: | Scipedia Open Access Scipedia SL Repositório Institucional da FIOCRUZ (ARCA) Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ International Journal of Cardiology: Heart & Vasculature, Vol 8, Iss C, Pp 75-80 (2015) International Journal of Cardiology. Heart & Vasculature |
| ISSN: | 2352-9067 |
| Popis: | Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Background: One of the most challenging issues of chronic Chagas disease is to provide earlier detection of heart involvement. Two-dimensional speckle tracking (2-D ST) echocardiography, a new imagingmodalitywith useful applications in several cardiac diseases, has been validated for subjects with myocardial infarction against cardiac magnetic resonance (CMR). Here we hypothesize that the longitudinal global strain (LGS) has an incremental value to ejection fraction for predicting myocardial fibrosis in subjects with Chagas disease. Methods: This observational study comprised 58 subjectswith Chagas disease, confirmed by two positive serologic tests. All subjects underwent conventional Doppler echocardiogramplus speckle tracking strain, and cardiacmagnetic resonance. Results: The ROC curve analysis revealed that both LGS (area under the curve: 0.78, p=0.001) and ejection fraction (area under the curve: 0.82, p b 0.001)were significant predictors ofmyocardial fibrosis. Regarding the percentage of fibrosis, a high correlation was observed with both ejection fraction assessed by echocardiography (r =0.70, p b 0.001) and LGS (r = 0.64, p b 0.001). However, when adjusted through multiple linear regression, the LGS lost statistical significance as a predictor of myocardial fibrosis (p = 0.111). Conclusions: LGS has no incremental value to conventional ejection fractionmeasurement in the prediction ofmyocardial fibrosis in subjects with Chagas disease. |
| Databáze: | OpenAIRE |
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