Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Autor:	Fahimeh Afzal Javan, Alireza Pasdar, Khadijeh Jamialahmadi, Mahdi Rivandi, Amir Avan, Mohsen Mohebati, Maryam Mardan-Nik, Majid Ghayour-Mobarhan, Gordon A. Ferns, Habibollah Esmaily, Atefeh Biabangard-Zak
Rok vydání:	2016
Předmět:	Adult Male 0301 basic medicine Aging medicine.medical_specialty Multivariate analysis Physiology Epidemiology Biology Bioinformatics Polymerase Chain Reaction Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Gene Frequency Internal medicine Diabetes mellitus Genotype Genetics medicine Humans Genetic Predisposition to Disease HSP70 Heat-Shock Proteins Obesity Allele Allele frequency Alleles Genetic Association Studies Aged Demography Models Genetic Public Health Environmental and Occupational Health Case-control study Middle Aged medicine.disease 030104 developmental biology Endocrinology Case-Control Studies 030220 oncology & carcinogenesis Female Gene polymorphism Polymorphism Restriction Fragment Length
Zdroj:	Annals of Human Biology. 43:542-546
ISSN:	1464-5033 0301-4460
DOI:	10.3109/03014460.2015.1119309
Popis:	Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity.The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects.Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity.The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls.The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b93a356f7140aa9a670a9b8bbc62778 https://doi.org/10.3109/03014460.2015.1119309 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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