Association between age and severity to leptospirosis in children

Autor: Yann Polfrit, Ann-Claire Gourinat, Isabelle Missotte, Pauline Hie, Emilie Huguon, Cyrille Goarant, Gilles Guerrier, Eric D'Ortenzio
Přispěvatelé: Intensive Care Unit, Centre Hospitalier Territorial, Paediatrics, Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur (RIIP)
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Pediatrics
Severity of Illness Index
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
MESH: Child
Case fatality rate
Child
0303 health sciences
education.field_of_study
biology
lcsh:Public aspects of medicine
Age Factors
MESH: Leptospirosis
MESH: Hospitals
Leptospirosis
Hospitals
3. Good health
Infectious Diseases
MESH: Survival Analysis
Female
Weil Disease
Research Article
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
Adolescent
lcsh:RC955-962
030231 tropical medicine
Population
03 medical and health sciences
New Caledonia
Leptospira
MESH: Severity of Illness Index
Severity of illness
medicine
Humans
education
Survival analysis
Retrospective Studies
MESH: Adolescent
MESH: Age Factors
MESH: Humans
030306 microbiology
business.industry
Public Health
Environmental and Occupational Health
lcsh:RA1-1270
Retrospective cohort study
MESH: Retrospective Studies
medicine.disease
biology.organism_classification
MESH: New Caledonia
Survival Analysis
MESH: Male
business
MESH: Female
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2013, 7 (9), pp.e2436. ⟨10.1371/journal.pntd.0002436⟩
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2436 (2013)
ISSN: 1935-2727
1935-2735
DOI: 10.1371/journal.pntd.0002436⟩
Popis: Background In endemic areas, leptospirosis is more common and more severe in adults compared with children. Reasons to explain this discrepancy remain unclear and limited data focusing on adolescents are available. The objective of the study was to describe disease spectrum and outcome differences in children and adolescents admitted for leptospirosis in a large at-risk population. Methods Clinical and laboratory data were obtained on hospitalized cases in New Caledonia from 2006 to 2012. Results Data of 60 patients
Author Summary Leptospirosis is endemic in tropical areas and seems to affect adults more often and more severely than children. Factors responsible for such differences have not been clearly established. However, host-related factors are believed to play a role in the development of severe leptospirosis. The study aimed to describe disease spectrum and outcome differences in confirmed cases in children and adolescents in New Caledonia. One major finding is the milder presentation of children compared with adolescents. Clinical and biological characteristics in adolescents are similar to adults, including occurrence of Jarisch-Herxheimer reactions. Further studies are required to explore age-dependant host factors, including puberty-related physiological changes.
Databáze: OpenAIRE
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