An incidental finding of pheochromocytoma in a 33-year-old patient with Lynch syndrome
| Autor: | Jan Podoba, Emília Mojtová, Gabriel Bognár, Marianna Grigerova, Štefan Kečkéš, Olívia Hamidová, Jana Hanajíková, D. Dyttert |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult endocrine system Pathology medicine.medical_specialty Colorectal cancer Adrenal Gland Neoplasms Pheochromocytoma Neuroendocrine tumors 03 medical and health sciences 0302 clinical medicine Ovarian carcinoma Internal Medicine medicine Carcinoma Humans neoplasms Incidental Findings business.industry medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis digestive system diseases Lynch syndrome 030104 developmental biology 030220 oncology & carcinogenesis Adenocarcinoma Female Skin cancer Cardiology and Cardiovascular Medicine business Colorectal Neoplasms |
| Zdroj: | Vnitrni lekarstvi. 66(5) |
| ISSN: | 0042-773X |
| Popis: | Pheochromocytoma is a catecholamine-producing neuroendocrine tumor arising from chromaffin cells of the adrenal medulla. The detection of these tumors is extremely important because they are associated with high cardiovascular morbidity and mortality. Progress in molecular genetics has revealed that up to 35% of pheochromocytomas are inhereted. Lynch syndrome (hereditary nonpolypous colorectal cancer - HNPCC) is an autosomal dominant genetic condition that is associated with a high risk of colorectal cancer or other extracolonic tumors (adenocarcinoma of endometrium, stomach, ovarian carcinoma, carcinoma of urinary tract, small intestine, brain tumors and skin cancer). Foreign medical journals are reporting an increasing number of cases on coexistence of HNPCC and neuroendocrine tumors, including pheochromocytoma. It increases the likelihood that this type of tumor could represent an additional extracolonic manifestation of Lynch syndrome. |
| Databáze: | OpenAIRE |
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