Molecular Mechanisms of Preeclampsia
| Autor: | Hod T, Ana Sofia Cerdeira, Karumanchi Sa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Placenta Diseases Placenta Prenatal diagnosis Disease Bioinformatics General Biochemistry Genetics and Molecular Biology Preeclampsia Pre-Eclampsia Pregnancy Prenatal Diagnosis Epidemiology medicine Humans Proteinuria Vascular Endothelial Growth Factor Receptor-1 business.industry medicine.disease female genital diseases and pregnancy complications embryonic structures Gestation Angiogenesis Inducing Agents Female medicine.symptom business Biomarkers Signal Transduction Perspectives |
| Zdroj: | Cold Spring Harbor perspectives in medicine. 5(10) |
| ISSN: | 2157-1422 |
| Popis: | Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension and proteinuria after 20 wk of gestation. It is a leading cause of maternal and fetal morbidity and mortality worldwide. Exciting discoveries in the last decade have contributed to a better understanding of the molecular basis of this disease. Epidemiological, experimental, and therapeutic studies from several laboratories have provided compelling evidence that an antiangiogenic state owing to alterations in circulating angiogenic factors leads to preeclampsia. In this review, we highlight the role of key circulating antiangiogenic factors as pathogenic biomarkers and in the development of novel therapies for preeclampsia. |
| Databáze: | OpenAIRE |
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