In vivo metabolism of benzo(a)pyrene in a lower vertebrate, the newt Pleurodeles walt
| Autor: | X.R. Michel, J.F. Narbonne, J. Marty, V. Ferrier |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pleurodeles
Health Toxicology and Mutagenesis chemistry.chemical_compound In vivo biology.animal polycyclic compounds Benzo(a)pyrene Animals Bile Radiometry Biotransformation Chromatography High Pressure Liquid biology Public Health Environmental and Occupational Health Vertebrate In vivo metabolism General Medicine Metabolism biology.organism_classification Pollution chemistry Biochemistry Liver Pyrene Environmental Pollutants Injections Intraperitoneal Half-Life Methylcholanthrene |
| Zdroj: | Ecotoxicology and environmental safety. 32(1) |
| ISSN: | 0147-6513 |
| Popis: | The capacity of the newt to metabolize benzo( a )pyrene in vivo was investigated qualitatively and quantitatively: metabolism was found to be rapid. Treatment of bile with β-glucuronidase and aryl-sulfatase released high proportions of diols and quinones, 3-Methylcholanthrene treatment shortened the elimination half-life of benzo( a )pyrene which was about three times shorter than the half-life found for non-3-methylcholanthrene-pretreated animals, Thus, a greater proportion of benzo( a )pyrene was converted into water-soluble products. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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