Structural Biology in the Multi-Omics Era
| Autor: | Caitlyn L. McCafferty, David W. Taylor, Edward M. Marcotte, Eric J. Verbeke |
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| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular 010304 chemical physics Extramural General Chemical Engineering Proteins Nanotechnology General Chemistry Library and Information Sciences Mass spectrometry 01 natural sciences Mass Spectrometry 0104 chemical sciences Computer Science Applications 010404 medicinal & biomolecular chemistry Structural biology Perspective 0103 physical sciences Multi omics Particle analysis Biology |
| Zdroj: | Journal of Chemical Information and Modeling |
| ISSN: | 1549-960X 1549-9596 |
| Popis: | Rapid developments in cryogenic electron microscopy have opened new avenues to probe the structures of protein assemblies in their near native states. Recent studies have begun applying single -particle analysis to heterogeneous mixtures, revealing the potential of structural-omics approaches that combine the power of mass spectrometry and electron microscopy. Here we highlight advances and challenges in sample preparation, data processing, and molecular modeling for handling increasingly complex mixtures. Such advances will help structural-omics methods extend to cellular-level models of structural biology. |
| Databáze: | OpenAIRE |
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