A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex
| Autor: | Maxime Henry, Corinne Ravelet, Valérie Guieu, Eric Dausse, Luc Choisnard, Jean-Jacques Toulmé, Guillaume Durand, Eric Peyrin, Laurent Azéma, Emma Goux |
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| Rok vydání: | 2017 |
| Předmět: |
Analyte
Aptamer Nanoparticle RNA Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Ligand (biochemistry) Colloidal Solution 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Nanosensor General Materials Science 0210 nano-technology DNA |
| Zdroj: | Nanoscale. 9:4048-4052 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c7nr00612h |
| Popis: | Herein, we report a novel approach for the design of a colorimetric aptasensor based on functionalized gold nanoparticle probes. This approach relies on the conjugation of nanoparticles by two functional DNA and RNA hairpins that engage specific kissing (loop-loop) interactions in response to the addition of a small analyte ligand, leading to particle aggregation and then red-to-purple colour change of the colloidal solution. |
| Databáze: | OpenAIRE |
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